3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-
Hexahydrocurcumin
CAS: 36062-05-2
Molecular Formula: C21H26O6
3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)- - Names and Identifiers
3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)- - Physico-chemical Properties
| Molecular Formula | C21H26O6 |
| Molar Mass | 374.43 |
| Density | 1.226 |
| Melting Point | 80-82℃ |
| Boling Point | 622.6±55.0 °C(Predicted) |
| Specific Rotation(α) | -10 (c, 0.28 in CHCl3) |
| Flash Point | 218℃ |
| Solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO |
| Appearance | neat |
| Color | Pale Yellow |
| BRN | 2486876 |
| pKa | 10.02±0.20(Predicted) |
| Storage Condition | 2-8°C |
3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)- - Risk and Safety
| WGK Germany | 3 |
3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)- - Reference
| Reference Show more | 1. [IF=4.946] Lai Yanni et al."3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase."Arch Pharm Res. 2020 May;43(5):489-502 |
3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)- - Reference Information
| biological activity | hexahydrocurrumin is one of the main metabolites of curcumin, which is a selective orally active COX-2 inhibitor, no activity on COX-1. Hexahydrocurrumin has antioxidant, anticancer and anti-inflammatory effects. |
| Cell Line: | HT-29 cells HT-29 cells HT-29 cells |
| Concentration: | 0 µM, 5 µM, 10 µM, 25 µM 25 µM 25 µM |
| Incubation Time: | 24 hours or 48 hours 24 hours 24 hours |
| Result: | Significantly decreased the viability of HT-29 colon cancer cells. Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 expression. Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 protein. Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression. |
| Animal Model: | Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH) |
| Dosage: | 50 mg/kg |
| Administration: | Oral administration; daily; for 16 weeks |
Last Update：2024-04-09 20:49:11
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Hexahydrocurcumin Visit Supplier Webpage Request for quotationCAS: 36062-05-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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